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Tuesday, May 13, 2025

Katalin Kariko

 Breaking Through

autobiographical memoir of

Hungarian American biochemist 

who specializes in RNA-mediated

mechanisms (2023 Crown, New York)

The mRNA molecule exists

temporarily, to deliver

a message.  I hope this

book, about my experiences

with mRNA, can deliver a

message or two:

We Can Do Better!

I believe we can improve

how science is done at

academic research

institutions.  For one

thing, we might create

a clearer distinction

between markers of

prestige

-- titles, publication

records, number of citations,

grant funding, committee

appointments, etiquette,

dollars per net square footage

-- and those of quality science.

Too often, we conflate the two,

as if they're one and the same.

But a person isn't a better

scientist because she publishes

more, or first.  Perhaps she's

holding back from publication

because she wants to be absolutely

certain of her data.  Similarly,

the number of citations might have

little to do with the value of the

paper and more to do with external

events. . .We can also expand the

criteria by which we measure our

scientists.  Most institutions

a scientist's value, first and 

foremost, by their funding.  But

most grants require a researcher

to define at a very high level of

detail what work they will do,

what discoveries they might make. . .

Science, at its best, is about

asking questions, trying things,

and going wherever that inquiry

takes you.  It requires walking 

into the unknown -- the unknown

is the very point!

(pages 315-6) ISBN 978-0-593-44316-3


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